ScienceDaily

Study finds how our brains turn into smarter disease fighters: Immune cell discovery a new attack on Alzheimer's, neurological disorders

Combating Alzheimer's and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists have found a way to safely thwart the brain's resistance to them, vaulting a key hurdle in the quest.

ScienceDaily

Silver nanoparticles show promise in fighting antibiotic-resistant bacteria

A new study found that small amounts of silver nanoparticles combined with a low dose of a common antibiotic inhibited the growth of resistant bacteria.

ScienceDaily

This one-atom chemical reaction could transform drug discovery: Researchers have stabilized atomic carbon for common reaction conditions in organic chemistry

Researchers have used single carbon atom doping to form four chemical bonds in one step. Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression). The team chemically modified an anti-seizure medication in 96% yield, highlighting the work's utility to otherwise synthetically complex aspects of pharmaceutical development. The results of this work could become foundational to drug discovery and development.

ScienceDaily

Study reveals how drug resistant bacteria secrete toxins, suggesting targets to reduce virulence

New research suggests that reducing virulence in drug resistant infections rather than trying to kill bacteria outright may offer an alternative approach to treatment. The study revealed how two proteins enable the methicillin-resistant Staphylococcus aureus (MRSA) bacterium to secrete the toxins that make people sick. The research suggests that therapies targeting these two proteins could disable MRSA, making it less deadly and possibly even harmless. Such an approach would also reduce the risk of promoting antibiotic resistance.

ScienceDaily

On-demand male contraceptive shows promise in preclinical study

An experimental contraceptive drug temporarily stops sperm in their tracks and prevents pregnancies in preclinical models. The study demonstrates that an on-demand male contraceptive is possible.

ScienceDaily

Psychostimulants: Cause of differences in duration and intensity of effect explored: Duration of binding to dopamine transporter makes the difference

Psychostimulants interacting with the dopamine transporter are found in the therapy of neuro-psychiatric disorders, such as ADHD or depression, as well as on the illicit drug market. In order to better understand their exact mode of action and undesirable effects, a research team has been working on the question of why different substances in this group of substances have different effects: According to their results the answer lies in the respective binding time of the substances to the dopamine transporter. This study has just been published in the journal Proceedings of the National Academy of Sciences (PNAS).

ScienceDaily

New antibiotic cures superbugs without bacterial resistance

In a potential game changer for the treatment of superbugs, a new class of antibiotics was developed that cured mice infected with bacteria deemed nearly 'untreatable' in humans -- and resistance to the drug was virtually undetectable.

ScienceDaily

Researchers unraveled new mechanisms behind articular cartilage healing after injury

Understanding how the knee joint environment affects cartilage cells is crucial for joint health. Knowledge of cell-driven cartilage degeneration mechanisms can support the development of effective pharmaceutical interventions for osteoarthritis. Researchers have now incorporated the influence of cells in a new numerical model to discover degeneration processes in mechanically loaded and inflamed cartilage.

ScienceDaily

Scientists develop novel approach to enhance drug delivery for brain tumors in children

Researchers have developed a new drug delivery approach that uses nanoparticles to enable more effective and targeted delivery of anti-cancer drugs to treat brain tumors in children.

ScienceDaily

'Semantic similarity' leads to novel drug candidates for Parkinson's disease: AI compares how compounds are described to find new drug leads

The words that researchers use to describe their results can be harnessed to discover potential new treatments for Parkinson's disease, according to a new study. The study employed an artificial intelligence (AI) system to identify an existing anti-cholesterol drug that has the ability to promote the disposal of mitochondria, energy-making components of the cell which are damaged in the disease.

« PREVIOUS4NEXT »