ScienceDaily

Adding antipsychotic med to antidepressant may help older adults with treatment-resistant depression

For older adults with clinical depression that has not responded to standard treatments, adding the drug aripiprazole to an antidepressant they're already taking is more effective than switching from one antidepressant to another, according to a new multicenter study.

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Hair analysis shows child drug use could be twice as high as we think: Experts recommend future substance use research should combine survey and hair analysis results

Hair analysis could be the key to understanding adolescent drug usage, as a new study uncovers almost double the number of children were found to be using substances than those who admitted to in a US survey.

ScienceDaily

First nasal monoclonal antibody treatment for COVID-19 shows promise for treating virus, other diseases: In a pilot trial and clinical sample-based investigations, the drug Foralumab decreased inflammatory markers in patients with COVID-19

A pilot trial tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody. Investigators found evidence that the drug dampened the inflammatory T cell response and decreased lung inflammation in patients with COVID-19. Further analysis showed the same gene expression modulation in patients with multiple sclerosis, who experienced decreased brain inflammation, suggesting that Foralumab could be used to treat other diseases.

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A new class of drugs could prevent resistant COVID-19 variants, study finds

The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains.

ScienceDaily

New stem cell model developed for research into a life-threatening malformation of the newborn lung: Study investigates cause and new therapeutic approach for congenital diaphragmatic hernia

Congenital diaphragmatic hernia is one of the deadliest birth defects. To better understand and treat this condition in the future, researchers designed a new cell model in the laboratory and tested a drug therapy on it.

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New drug to lower brain pressure could treat blinding IIH headaches, trial finds: Phase two trial first study to show rapid and significant reduction in pressure in the brain and monthly headaches

Patients with 'blinding' headaches known as Idiopathic Intercranial Hypertension (IIH) could be treated with a GLP-1RA peptide used for type 2 diabetes, a new phase 2 trial has found.

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Triggering bitter taste receptors could someday treat asthma, COPD

Surprisingly, bitter taste receptors are not only located in the mouth, but also elsewhere in the body, including the airways. Activating those receptors opens up lung passageways, so they're a potential target for treating asthma or chronic obstructive pulmonary disease (COPD). Now, researchers report that they have designed a potent and selective compound that could lead the way to such therapies.

ScienceDaily

Study sheds light on concerning new trend in drug advertising: Patient influencers

Pharmaceutical companies are increasingly partnering with real patients, or patient influencers, who share their experiences and advice on social media. A new study offers a first glimpse at why and how they do it.

ScienceDaily

Study unravels a cause of resistance to novel drug in patients with acute leukemia

A new targeted drug has not only sparked remissions in patients with a common form of leukemia but also induced the cancer cells to reveal one of their schemes for resisting the drug, investigators report in a new pair of studies.

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Fomepizole helps overcome antibiotic-resistant pneumonia in mice, study finds

Pneumococcal disease leads to over three million hospitalizations and hundreds of thousands of deaths annually. A new study suggests that the FDA-approved drug Fomepizole may reduce disease severity in the lungs of mice with some forms of bacterial pneumonia and enhance the efficacy of the antibiotic erythromycin as well.

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