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Protein engineers navigate toward more targeted therapeutics: New research on protein receptors could lead to breakthroughs in improving drug delivery.

Researchers uncovered the role of the third intracellular loop in the G protein-coupled receptors' signaling mechanism, which could lead to a more targeted approach to drug discovery and a paradigm shift for new therapeutics.

ScienceDaily

Resistant bacteria are a global problem. Now researchers may have found the solution

A new substance has proven useful for treating staphylococcus infections in people with skin lymphoma. This is good news for the patients, but also for the global threat of antibiotics resistance.

ScienceDaily

New combination of drugs works together to reduce lung tumors in mice

A new study has revealed FDA-approved trametinib and entinostat (which is currently in clinical trials) can be given in tandem to produce fewer and smaller tumors in mice with LKB1-mutated non-small cell lung cancer.

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Nanotechnology could treat lymphedema

When lymphatic vessels fail, typically their ability to pump out the fluid is compromised. Researchers have now developed a new treatment using nanoparticles that can repair lymphatic vessel pumping. Traditionally, researchers in the field have tried to regrow lymphatic vessels, but repairing the pumping action is a unique approach.

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Novel immunotherapy agent safe, shows promise against high-risk prostate cancers

A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study. If confirmed in additional studies, enoblituzumab could become the first promising antibody-based immunotherapy agent against prostate cancer.

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Implantable device shrinks pancreatic tumors: Taming pancreatic cancer with intratumoral immunotherapy

Nanomedicine researchers have found a way to tame pancreatic cancer -- one of the most aggressive and difficult to treat cancers -- by delivering immunotherapy directly into the tumor with a device that is smaller than a grain of rice.

ScienceDaily

How drugs get into the blood

Computer simulations have helped researchers understand in detail how pharmaceutically active substances cross cell membranes. These findings can now be used to discover new drug candidates more efficiently.

ScienceDaily

Molecular 'Superpower' of antibiotic-resistant bacteria

A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings. A study now shows how two molecular mechanisms can work together make the bacterium extra resistant.

ScienceDaily

Wonder drug-capsule may one day replace insulin injection for diabetics

Scientists have designed a new type of oral capsule that could mean pain-free delivery of insulin and other protein drugs. Protein drugs had proven challenging to deliver orally as the drugs degrade very quickly in the stomach -- until now.

ScienceDaily

Nanoparticles provoke immune response against tumors but avoid side effects: In a new study, immunostimulatory drugs slowed tumor growth without producing systemic inflammation

Researchers find that when immunostimulatory drugs called imidazoquinolines are delivered using specialized bottlebrush nanoparticles, the drugs provoke the immune system to attack tumors while eliminating the side effects that occur when the drugs are given on their own.

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