ScienceDaily

Drug combination restores ability of leading treatment to signal for death of blood cancer cells: Future clinical trials to determine if combination chloroquine and venetoclax addresses disease comeback

Despite the promise of new medications that promote cancer cell death in people with acute myeloid leukemia, leukemic cells often adopt features that let them evade the drugs' effects within a year.

ScienceDaily

New biologic effective against major infection in early tests

A research team has shown in early tests that a bioengineered drug candidate can counter infection with Staphylococcus aureus -- a bacterial species widely resistant to antibiotics.

ScienceDaily

First 'gene silencing' drug for Alzheimer's disease shows promise

A new trial has found a new genetic therapy for Alzheimer's disease that is able to safely and successfully lower levels of the harmful tau protein known to cause the disease.

ScienceDaily

New test reveals existing antibiotics, hiding in plain sight on pharmacy shelves, can treat superbugs

A new test revealed that FDA-approved antibiotics -- available at your neighborhood pharmacy -- can effectively treat superbugs. They are not prescribed, however, because the gold-standard test predicts they will not work. The new test may improve the way antibiotics are developed, tested and prescribed -- and it is openly available to all.

ScienceDaily

To boost cancer immunotherapy's fighting power, look to the gut: Study reveals how gut microbes alter the body's response to cancer immunotherapy

Immunotherapy has redefined cancer treatment, but not all patients experience the same benefit when treated. New research in mice identifies how gut bacteria alter the body's response to a common form of cancer immunotherapy. The animals' gut microbiota lowered the expression of two immune molecules, one previously unknown to play a role in cancer. • Using antibodies to block the activity of either molecule, or the interplay between them, enhanced response to cancer immunotherapy. • The findings can inform the design of treatments that boost the efficacy of cancer immunotherapy among patients with suboptimal response.

ScienceDaily

Cellular traffic controllers caught managing flow of signals from receptors: First time that individual beta-arrestin molecules are directly observed as they control receptor-mediated signals in living cells using advanced microscopy

Proteins that act like air traffic controllers, managing the flow of signals in and out of human cells, have been observed for the first time with unprecedented detail using advanced microscopy techniques. New findings could inform the development of better drugs for pain relief, diabetes or heart failure.

ScienceDaily

A better route to benzocyclobutenes, sought-after buildingblocks for drugs

Chemists devise a new, C-H activation-based method for the synthesis of BCBs.

ScienceDaily

New chemical compound demonstrates potential in nerve regeneration

Recent research has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen in heart attack.

ScienceDaily

Using AI, scientists find a drug that could combat drug-resistant infections: The machine-learning algorithm identified a compound that kills Acinetobacter baumannii, a bacterium that lurks in many hospital settings.

Using AI, researchers identified a new antibiotic that can kill Acinetobacter baumannii, a type of bacteria that is responsible for many drug-resistant infections.

ScienceDaily

Using AI to create better, more potent medicines: Novel framework could offer chemists greater drug options

While it can take years for the pharmaceutical industry to create medicines capable of treating or curing human disease, a new study suggests that using generative artificial intelligence could vastly accelerate the drug-development process.

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